May 13, 1998 – The Preble's meadow jumping mouse was listed as threatened as the result of a 1994 petition from the Biodiversity Legal Foundation (later to become part of the Center for Biological Diversity).
2001 – The U.S. Fish and Wildlife Service adopted a special rule allowing harm to Preble's mice under certain conditions, including situations involving rodent control and agricultural activities.
June 23, 2003 – Despite an original critical habitat proposal of 57,000 acres, only 31,000 acres of critical habitat were designated for the mouse.
August 28, 2007 – The Center filed a notice of intent to sue the Bush administration for its insufficient 2003 designation of critical habitat for the mouse, as well as for 54 other tainted Endangered Species Act decisions.
November 7, 2007 – The Service proposed the mouse for delisting in Wyoming, to retain protection only in the Colorado portion of its range. After the Center submitted extensive comments, the Service announced it would reexamine the proposal. At the same time, it agreed to reexamine its 2003 critical habitat decision.
July 10, 2008 – The Service announced it would delist the Preble's meadow jumping mouse in Wyoming despite the recommendations of scientists, claiming the mouse should only receive protections where threats are the greatest.
June 23, 2009 – The Center for Biological Diversity, the Center for Native Ecosystems, the Biodiversity Conservation Alliance, Natural Resources Defense Council and Defenders of Wildlife filed suit over the Bush administration's decision to remove protections for the Preble's meadow jumping mouse in Wyoming.
December 15, 2010 – The mouse's critical habitat was revised to include a total of 411 miles of rivers and streams and 34,935 acres in Boulder, Broomfield, Douglas, El Paso, Jefferson, Larimer and Teller counties.
July 2011 – A judge ruled that Endangered Species Act protection must be restored to the Preble's meadow jumping mouse in Wyoming after the Center helped repeal the Bush-era policy that allowed a species to be protected in one part of its range and not another.
August 4, 2011 –The Fish and Wildlife Service announced it would officially reinstate protections for the Preble's meadow jumping mouse as a threatened species under the Endangered Species Act throughout its range, including Wyoming.