October 9, 2001 – The scaleshell mussel gains Endangered Species Act protection as the result of a Center lawsuit.
May 4, 2004 – The Center files a petition seeking protection for nine freshwater mussels.
April 20, 2010 – The Center files a petition seeking protection for 48 freshwater mussels from the southeastern United States.
September 9, 2011 – The Center reaches a landmark settlement agreement with the U.S. Fish and Wildlife Service to expedite protection decisions for 757 species including 55 mussels.
October 11, 2011 – The Altamaha spinymussel, which the Center first petitioned for in 2004, gains Endangered Species Act protection.
October 2012 – Ten freshwater mussels from the southeastern United States gain Endangered Species Act protection as the result of Center petitions and lawsuits, including the fuzzy pigtoe, narrow pigtoe, tapered pigtoe, round ebonyshell, southern sandshell, Choctaw bean, Alabama pearlshell, slabside pearlymussel, southern kidneyshell and fluted kidneyshell.
February 2012 – The Center and allies save a mussel bed on the Ohio River in Kentucky from being filled in to construct a marina, protecting the orangefoot pimpleback, fat pocketbook and other species.
February 14, 2012 – The snuffbox and rayed bean gain Endangered Species Act protection resulting from the Center's work.
March 13, 2012 – The sheepnose and spectaclecase gain Endangered Species Act protection as the result of Center advocacy.
March 18, 2013 – The Center and allies save a freshwater mussel nursery from being shut down by the Tennessee Valley Authority on the Cumberland River, protecting pink muckets and other
September 17, 2013 – The rabbitsfoot and Neosho mucket achieve protected status resulting from Center petitions and lawsuits.
August 13, 2014 – The Center files a lawsuit challenging the state of Kentucky's weakening of water-quality laws in order to uphold a standard that is protective of freshwater mussels and other endangered aquatic animals.
January 23, 2015 – The Center petitioned the Fish and Wildlife Serviceto designate critical habitat for nine endangered species — including the James spinymussel, dwarf wedgemussel and clubshell?James spinymussel, dwarf wedgemussel, and clubshell — that are among more than 600 federally protected species illegally denied specific habitat protections since 1978.
April 4, 2017 – In response to an agreement with the Center, the U.S. Fish and Wildlife Service proposed Endangered Species Act protection for the yellow lance, a freshwater mussel that lives in Maryland, North Carolina and Virginia.